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CyFlow™ ABRA1 Purified

CyFlow™ ABRA1 Purified
Application: Flow cytometry, Immunoprecipitation, Western blot
Clonality: monoclonal
Target Species: Human
Regulatory Status: RUO
Source Species: Mouse
Format/Fluorochrome: Purified
Isotype: IgG
Antigen: ABRA1
Clone: ABRA1-01
Field of Interest: Adaptor proteins, Transcription
Order number: AP667270
ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of... more
Product information "CyFlow™ ABRA1 Purified"
ABRA1 (Abraxas, CCDC98) is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.
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