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CyFlow™ Beta-catenin Purified
| Application: | Flow cytometry, Immunocytochemistry, Immunoprecipitation, Western blot |
| Target Species: | Hamster, Human, Mouse |
| Clone: | EM-22 |
| Field of Interest: | Adaptor proteins, Cytoskeleton, Transcription |
| Clonality: | monoclonal |
| Isotype: | IgG1 |
| Format/Fluorochrome: | Purified |
| Source Species: | Mouse |
| Regulatory Status: | RUO |
| Antigen: | β-catenin |
| Order number: | BP858553 |
For Research Use Only
Not for use in diagnostic or therapeutic procedures.
Concentration Unit mg/mL Concentration 1 Quantity 0.1 mg Volume 0.1 mL... more
Product information "CyFlow™ Beta-catenin Purified"
| Concentration Unit | mg/mL |
| Concentration | 1 |
| Quantity | 0.1 mg |
| Volume | 0.1 mL |
| Immunogen | Recombinant human β-catenin |
| Background Information | β-catenin is a multifunctional protein involved both in cell adhesion and in activation of transcription. Calcium-dependent intercellular adhesion transmembrane glycoprotein E-cadherin interacts by its cytoplasmic domain with reciprocally bound α, β and γ catenin. β-catenin links this complex through α-actinin to the cytoskeleton. Functional cadherin-catenin system is important for invasiveness of tumor cells. β-catenin level in cytoplasm is controlled by glycogen synthase kinase-3 β. When activity of this kinase is blocked (e.g. by excessive stimulation of Wnt signaling pathway), hypophosphorylated stable form of β-catenin accumulates in the cytoplasm, translocates to the nucleus and activates transcription of genes including those that are involved in cell cycle control. As a result, cell division and neoplastic transformation are promoted. |
| Storage Buffer | The reagent is provided in phosphate buffered saline (PBS) solution, pH ≈7.4, containing 0.09% (w/v) sodium azide. |
| Storage | Avoid prolonged exposure to light. Store in the dark at 2-8°C. Do not freeze. |
| Stability | Do not use after expiration date stamped on vial label. |
Technical Data Sheet
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